| Title | Elevated Serum Polybrominated Diphenyl Ethers and Thyroid-Stimulating Hormone Associated with Lymphocytic Micronuclei in Chinese Workers from an E-Waste Dismantling Site |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Yuan J, Chen L, Chen D, Guo H, Bi X, Ju Y, Jiang P, Shi J, Yu Z, Yang J, Li L, Jiang Q, Sheng G, Fu J, Wu T, Chen X |
| Journal Title | Environmental Science & Technology |
| Volume | 42 |
| Pages | 2195-2200 |
| ISBN Number | 0013-936x |
| Abstract | Abstract: In this study, we recruited 49 subjects from one village close to an electronic waste (e-waste) site (exposed group) and another located 50 km away from the e-waste site (control group). We found that serum levels of polybrominated diphenyl ethers (median PBDEs, 382 ng/g lipid weight; range, 77 8452 ng/g lipid weight) and thyroid-stimulating hormone (median TSH, 1.79 µIU/mL; range, 0.38 9.03 µIU/mL) and frequencies of micronucleated binucleated cells (MNed BNC; median, 50; range, 0 960) were significantly higher in the exposed group than in the control group (158 ng/g, range of 18 436 ng/g, and p < 0.05; 1.15 µIU/mL, range of 0.48 2.09, and p < 0.01; and 00, range of 0 50, and p < 0.01, respectively). A history of working with e-waste was significantly associated with increased MNed BNC frequencies (odds ratio (OR), 38.85; 95% confidence interval (CI) = 1 1358.71, p = 0.044), independent of years of local residence, a perceived risk factor. However, there was no association between PBDEs exposure and oxidative DNA damage. Therefore, the exposure to PBDEs at the e-waste site may have an effect on the levels of TSH and genetoxic damage among these workers, but this needs to be validated in large studies. |
| URL | http://pubs3.acs.org/acs/journals/doilookup?in_doi=10.1021/es702295f |
Elevated Serum Polybrominated Diphenyl Ethers and Thyroid-Stimulating Hormone Associated with Lymphocytic Micronuclei in Chinese Workers from an E-Waste Dismantling Site
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